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Lysine Acetylation Goes Global: From Epigenetics to Metabolism and Therapeutics
Chemical Reviews ( IF 62.1 ) Pub Date : 2018-02-06 00:00:00 , DOI: 10.1021/acs.chemrev.7b00181
Ibraheem Ali 1, 2 , Ryan J. Conrad 1, 2 , Eric Verdin 3 , Melanie Ott 1, 2
Affiliation  

Post-translational acetylation of lysine residues has emerged as a key regulatory mechanism in all eukaryotic organisms. Originally discovered in 1963 as a unique modification of histones, acetylation marks are now found on thousands of nonhistone proteins located in virtually every cellular compartment. Here we summarize key findings in the field of protein acetylation over the past 20 years with a focus on recent discoveries in nuclear, cytoplasmic, and mitochondrial compartments. Collectively, these findings have elevated protein acetylation as a major post-translational modification, underscoring its physiological relevance in gene regulation, cell signaling, metabolism, and disease.

中文翻译:

赖氨酸乙酰化走向全球:从表观遗传学到新陈代谢和治疗学

赖氨酸残基的翻译后乙酰化已成为所有真核生物中的关键调控机制。乙酰化标记最初于1963年发现,是对组蛋白的独特修饰,如今在几乎每个细胞区室中的数千种非组蛋白蛋白上都发现了乙酰化标记。在这里,我们总结了过去20年中蛋白质乙酰化领域的主要发现,重点是核,细胞质和线粒体区室中的最新发现。总的来说,这些发现将蛋白质乙酰化提高为主要的翻译后修饰,强调了其在基因调节,细胞信号传导,代谢和疾病中的生理相关性。
更新日期:2018-02-06
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