Seven previously undescribed jatrophane diterpenoids, nicaeenin A-G, with eight known jatrophane diterpenoids, namely euphodendrophanes A-C, F, N, O, Q, S, were isolated from latex of Euphorbia nicaeensis collected in Serbia. The chemical structures of the compounds were determined by spectroscopic analysis including 1D and 2D NMR and HRESIMS experiments. All but one of the previously undescribed jatrophanes, showed significant potential to inhibit P-glycoprotein (P-gp) activity in two MDR cancer cells (NCI-H460/R and DLD1-TxR). The most powerful were nicaeenin F and nicaeenin G. Moreover nicaeenin G significantly stronger sensitized NCI-H460/R cells to DOX than Dex-VER.

中文翻译：

---

来自大戟胶乳的具有多药抗性调节活性的麻风树二萜类化合物

从塞尔维亚收集的 Euphorbia nicaeensis 乳胶中分离出 7 种以前未描述的麻风树二萜类化合物，nicaeenin AG，以及 8 种已知的麻风树二萜类化合物，即大戟烷 AC、F、N、O、Q、S。化合物的化学结构通过光谱分析确定，包括一维和二维核磁共振和 HRESIMS 实验。除了先前未描述的麻风树中的一种外，所有其他物质都显示出抑制两种 MDR 癌细胞（NCI-H460/R 和 DLD1-TxR）中 P-糖蛋白 (P-gp) 活性的显着潜力。最强大的是尼卡伊宁 F 和尼卡伊宁 G。此外，与 Dex-VER 相比，尼卡恩 G 显着更强地使 NCI-H460/R 细胞对 DOX 敏感。