Protein imprinted polymers have received a lot of interest in the past few years because of their applications as tailor-made receptors for biomacromolecules. Generally, the preparation of these polymers requires numerous and time-consuming steps. But their coupling with magnetic nanoparticles simplifies and speeds up the synthesis of these materials. Some recent papers describe the use of protein imprinted polymer (PIP) coupled to magnetic iron oxide nanoparticles (MION) for the design of MION@PIP biosensors. With such systems, a target protein can be specifically and selectively captured from complex media due to exceptional chemical properties of the polymer. Despite such performances, only a limited number of studies address these hybrid nanosystems. This review focuses on the chemistry and preparation of MION@PIP nanocomposites as well as on the metrics used to characterize their performances.

中文翻译：

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磁性蛋白质印迹聚合物：综述

在过去的几年中，蛋白质印迹聚合物因其作为生物大分子的量身定制的受体而得到了广泛的关注。通常，这些聚合物的制备需要许多耗时的步骤。但是它们与磁性纳米粒子的结合简化并加速了这些材料的合成。最近的一些论文描述了将蛋白质印迹聚合物（PIP）与磁性氧化铁纳米颗粒（MION）耦合用于MION @ PIP生物传感器的设计。利用这种系统，由于聚合物的优异化学性质，可以从复杂的介质中特异性地和选择性地捕获靶蛋白。尽管有这样的表现，但是只有有限的研究针对这些混合纳米系统。