Drive is a process of accelerated inheritance from one generation to the next that allows some genes to spread rapidly through populations even if they do not contribute to-or indeed even if they detract from-organismal survival and reproduction. Genetic elements that can spread by drive include gametic and zygotic killers, meiotic drivers, homing endonuclease genes, B chromosomes, and transposable elements. The fact that gene drive can lead to the spread of fitness-reducing traits (including lethality and sterility) makes it an attractive process to consider exploiting to control disease vectors and other pests. There are a number of efforts to develop synthetic gene drive systems, particularly focused on the mosquito-borne diseases that continue to plague us.

中文翻译：

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基因驱动：进化和综合。

驱动是从一代到下一代加速遗传的过程，它使某些基因即使在没有贡献的情况下也可以在整个种群中迅速传播，或者甚至即使它们减损了生物的生存和繁殖。可以通过驱动传播的遗传元素包括配子和合子杀手，减数分裂驱动子，归巢核酸内切酶基因，B染色体和转座因子。基因驱动会导致降低适应性的性状（包括致死性和不育性）的传播，这一事实使得考虑利用其来控制病媒和其他害虫成为一个有吸引力的过程。在开发合成基因驱动系统方面已进行了许多努力，特别是针对继续困扰我们的蚊媒疾病。