Vanadium‐Catalyzed N‐Benzoylation of 2‐Aminopyridines via Oxidative C(CO)−C(CO) Bond Cleavage of 1,2‐Diketones, N→N′ Aroyl Migration and Hydrolysis of 2‐(Diaroylamino)pyridines,Asian Journal of Organic Chemistry

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Vanadium‐Catalyzed N‐Benzoylation of 2‐Aminopyridines via Oxidative C(CO)−C(CO) Bond Cleavage of 1,2‐Diketones, N→N′ Aroyl Migration and Hydrolysis of 2‐(Diaroylamino)pyridines
Asian Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2018-03-07 , DOI: 10.1002/ajoc.201800012
Chander Singh Digwal ₁ , Upasana Yadav ₁ , P. V. Sri Ramya ₁ , Baijayantimala Swain ₁ , Ahmed Kamal _{1,

2}

Affiliation

A one‐pot route to synthesize pyridylbenzamides has been developed via vanadium‐catalyzed C(CO)−C(CO) bond cleavage of 1,2‐diketones with 2‐aminopyridines, N→N′ aroyl migration, and hydrolysis of in situ generated 2‐(diaroylamino) pyridines. This method offers a simple, neutral, and practical approach to access various medicinally important pyridylbenzamides under base‐, additive‐ and external oxidant‐free conditions.

中文翻译：

钒催化1,2-二酮的氧化C（CO）-C（CO）键裂解2-氨基吡啶的N-苄基化，N→N'芳基迁移和2-（二芳酰氨基）吡啶的水解

通过钒催化的1,2-二酮与2-氨基吡啶的C（CO）-C（CO）键裂解，N→N'芳酰基迁移以及原位生成的水解反应，开发了一种单吡啶路线合成吡啶基苯甲酰胺。 2-（二酰氨基）吡啶。该方法提供了一种简单，中性和实用的方法，可在无碱，无添加剂和无外部氧化剂的条件下使用各种对医学有重要意义的吡啶基苯甲酰胺。

更新日期：2018-03-07

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