Two‐dimensional (2D) MXenes, as a new 2D functional material nanosystem, have been extensively explored for broad applications. However, their specific performance and applications in theranostic nanomedicine have still rarely been explored. This work reports on the drug‐delivery performance and synergistic therapeutic efficiency of Ti₃C₂ MXenes for highly efficient tumor eradication. These Ti₃C₂ MXenes not only possess high drug‐loading capability of as high as 211.8%, but also exhibit both pH‐responsive and near infrared laser‐triggered on‐demand drug release. Especially, based on the high photothermal‐conversion capability of Ti₃C₂ MXenes, they have been further explored for efficient tumor eradication by synergistic photothermal ablation and chemotherapy, which has been systematically demonstrated both in vitro and in vivo. These Ti₃C₂ MXenes have also been demonstrated as the desirable contrast agents for photoacoustic imaging, showing the potential for diagnostic‐imaging guidance and monitoring during therapy. The high in vivo histocompatibility of Ti₃C₂ and their easy excretion out of the body have been evaluated and demonstrated, showing the potential high biosafety for further clinical translation. This work paves a new way for broadening biomedical applications of MXenes in nanomedicine where they can exert the high performance and functionality for synergistic therapy, especially on combating cancer.

中文翻译：

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基于二维超薄MXene的药物递送纳米平台，用于协同光热消融和化学疗法治疗癌症。

二维（2D）MXene作为一种新的2D功能材料纳米系统，已经得到了广泛的应用。然而，仍然很少探索其在治疗性纳米医学中的特定性能和应用。这项工作报告了Ti ₃ C ₂ MXenes在高效消灭肿瘤方面的药物传递性能和协同治疗效率。这些Ti ₃ C ₂ MXenes不仅具有高达211.8％的高载药能力，而且还具有pH响应和近红外激光触发的按需释放。特别是基于Ti ₃ C ₂的高光热转化能力MXenes已通过协同光热消融和化学疗法进一步探索了其有效消灭肿瘤的能力，这已在体外和体内得到了系统证明。这些Ti ₃ C ₂ MXenes也已被证明是用于光声成像的理想造影剂，显示出在治疗过程中进行诊断成像指导和监测的潜力。Ti ₃ C _2的体内高组织相容性已经对其进行了评估，并证明了它们易于从体内排泄出来，显示出潜在的高生物安全性，可用于进一步的临床翻译。这项工作为扩大MXene在纳米医学中的生物医学应用铺平了新途径，它们可以发挥协同作用的高性能和功能性，特别是在抗癌方面。