The Consortium for Top-Down Proteomics (CTDP) proposes a standardized notation, ProForma, for writing the sequence of fully characterized proteoforms. ProForma provides a means to communicate any proteoform by writing the amino acid sequence using standard one-letter notation and specifying modifications or unidentified mass shifts within brackets following certain amino acids. The notation is unambiguous, human-readable, and can easily be parsed and written by bioinformatic tools. This system uses seven rules and supports a wide range of possible use cases, ensuring compatibility and reproducibility of proteoform annotations. Standardizing proteoform sequences will simplify storage, comparison, and reanalysis of proteomic studies, and the Consortium welcomes input and contributions from the research community on the continued design and maintenance of this standard.

中文翻译：

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ProForma：标准蛋白形式表示法

自上而下的蛋白质组学联合会（CTDP）提出了一种标准化的符号ProForma，用于编写完全特征化的蛋白形式的序列。ProForma提供了一种交流任何蛋白形式的方法，方法是使用标准的一个字母表示法编写氨基酸序列，并在某些氨基酸之后的括号内指定修饰或未确定的质量偏移。该符号是明确的，人类可读的，并且可以很容易地由生物信息学工具进行解析和编写。该系统使用七个规则，并支持各种可能的用例，从而确保了蛋白形式注释的兼容性和可重复性。标准化蛋白形序列将简化蛋白组学研究的存储，比较和重新分析，