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Structural Diversity and Anticancer Activity of Marine‐Derived Elastase Inhibitors: Key Features and Mechanisms Mediating the Antimetastatic Effects in Invasive Breast Cancer
ChemBioChem ( IF 3.2 ) Pub Date : 2018-03-23 , DOI: 10.1002/cbic.201700627
Fatma H. Al-Awadhi 1, 2, 3 , Valerie J. Paul 4 , Hendrik Luesch 1, 2
Affiliation  

Cyanobacteria against cancer: Chemical exploration of a marine cyanobacterium led to the discovery of three new elastase inhibitors, loggerpeptins A–C, along with molassamide, that might be valuable for anticancer therapeutics. Molassamide was the most potent analogue and inhibited cleavage of CD40 and expression and cleavage of downstream target ICAM‐1, as well as elastase‐induced migration of invasive breast cancer cells.
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中文翻译:

海洋衍生的弹性蛋白酶抑制剂的结构多样性和抗癌活性:介导侵袭性乳腺癌的抗转移作用的关键特征和机制。

蓝藻抗癌:对海洋蓝细菌的化学勘探导致发现了三种新的弹性蛋白酶抑制剂,记录蛋白酶A–C和糖蜜,可能对抗癌治疗有价值。Molassamide是最有效的类似物,可抑制CD40的裂解,下游靶标ICAM-1的表达和裂解以及弹性蛋白酶诱导的侵袭性乳腺癌细胞的迁移。
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更新日期:2018-03-23
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