Chiral helical polymer nanoparticles have constituted a significant category of advanced functional particles by creatively combining chirality with nanoscale size into one unity. However, their further progress has been confronted with intractable difficulties, especially due to the limited kinds and number of chiral monomers and the lack of effective and universal preparation methods. In this study, the first protocol, that is, dispersion polymerization, for preparing monodispersed, chiral helical polymer nanoparticles derived from substituted acetylenic monomers, is reported. The possible formation mechanism of polymer nanoparticles is proposed. More excitingly, achiral monomers subsequently undergo helix‐sense‐selective dispersion polymerization with d(l)‐lactide as chiral additive, directly leading to optically active helical polymer nanoparticles. The present study not only provides a novel approach for preparing chiral helical polymer nanoparticles but also significantly expands the type and number of monomers for constructing chiral nanoparticles.

中文翻译：

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手性源存在下取代乙炔的分散聚合制备单分散手性纳米粒子

通过创造性地将手性与纳米级尺寸组合为一个整体，手性螺旋聚合物纳米粒子已构成一类重要的高级功能粒子。然而，它们的进一步发展面临着棘手的困难，特别是由于手性单体的种类和数量有限以及缺乏有效和通用的制备方法。在这项研究中，报道了用于制备衍生自取代炔属单体的单分散手性螺旋聚合物纳米粒子的第一种方案，即分散聚合。提出了聚合物纳米粒子的可能形成机理。更令人兴奋的是，非手性单体随后进行了d（l）-丙交酯作为手性添加剂，直接产生旋光性螺旋聚合物纳米粒子。本研究不仅提供了一种制备手性螺旋聚合物纳米粒子的新颖方法，而且还大大扩展了用于构建手性纳米粒子的单体的类型和数量。