Bone scientists are actively investigating a range of methods to promote skeletal tissue regeneration. A review of recent literature has revealed that several ions are uniquely capable of inducing stem cell differentiation down desired lineages. There exists enormous promise for these ions to be used in bone regenerative medicine. Given that these ions can be released from biodegradable polymeric materials, their long-term delivery can be achieved through a variety of controlled-release strategies compared with the relatively few options available for expensive and fragile polypeptide-based growth factors. In this review, we highlight the developments in using ions in conjunction with biomaterials for bone regeneration.

骨骼科学家正在积极研究各种促进骨骼组织再生的方法。对最近文献的回顾表明，几种离子独特地能够诱导干细胞向所需谱系分化。这些离子在骨再生医学中具有广阔的前景。鉴于这些离子可以从可生物降解的聚合物材料中释放出来，与昂贵和脆弱的基于多肽的生长因子的可用选择相比，通过各种控释策略可以实现它们的长期传递。在这篇综述中，我们重点介绍了将离子与生物材料结合用于骨骼再生的发展。