As a natural polymer, albumin is well-received for being nontoxic, nonimmunogenic, biodegradable and biocompatible. Together with its targeting potential on specific cells, albumin-based nanoparticles appear as an effective carrier for various therapeutics. In recent years, there has been an increasing number of studies investigating the use of albumin-based nanoparticles across different administration routes. Although each route and target tissue presents a distinct anatomical and physiological profile that demands specific consideration, pharmaceuticals could still be delivered effectively via albumin-based nanoparticles. Therefore, this review discusses the features that warrant such applications across various delivery routes and explores their possibilities in other administration routes. The challenges associated with its use will also be elaborated to provide a holistic consideration to realise their clinical potentials.

作为一种天然聚合物，白蛋白因无毒，无免疫原性，可生物降解和生物相容性而广受好评。基于白蛋白的纳米颗粒及其对特定细胞的靶向潜力，似乎是各种治疗方法的有效载体。近年来，越来越多的研究调查了跨不同给药途径使用基于白蛋白的纳米颗粒。尽管每种途径和目标组织都呈现出独特的解剖结构和生理特征，需要进行特殊考虑，但仍可以通过基于白蛋白的纳米颗粒有效地递送药物。因此，本文将讨论保证跨各种交付途径进行此类应用的功能，并探讨其在其他管理途径中的可能性。