Wound healing is a complex process, which ultimately leads to fibrosis if not repaired well. Pathologically very similar to fibrosis is the tumor stroma, found in several solid tumors which are regarded as wounds that do not heal. Integrins are heterodimeric surface receptors which control various physiological cellular functions. Additionally, integrins also sense ECM-induced extracellular changes during pathological events, leading to cellular responses, which influence ECM remodeling. The purpose and scope of this review is to introduce integrins as key targets for therapeutics and drug delivery within the scope of wound healing, fibrosis and the tumor stroma. This review provides a general introduction to the biology of integrins including their types, ligands, means of signaling and interaction with growth factor receptors. Furthermore, we highlight integrins as key targets for therapeutics and drug delivery, based on their biological role, expression pattern within human tissues and at cellular level. Next, therapeutic approaches targeting integrins, with a focus on clinical studies, and targeted drug delivery strategies based on ligands are described.

伤口愈合是一个复杂的过程，如果修复得不好，最终会导致纤维化。病理学上与纤维化非常相似的是肿瘤基质，它存在于几种实体瘤中，这些实体瘤被视为无法愈合的伤口。整联蛋白是控制各种生理细胞功能的异二聚体表面受体。另外，整联蛋白还可以在病理事件期间感知ECM诱导的细胞外变化，从而导致细胞反应，从而影响ECM重塑。本文的目的和范围是在伤口愈合，纤维化和肿瘤基质的范围内，引入整联蛋白作为治疗和药物输送的主要靶标。这篇综述提供了整联蛋白的生物学概述，包括它们的类型，配体，信号传导方式以及与生长因子受体的相互作用。此外，我们将基于整合素的生物学作用，在人体组织中以及在细胞水平上的表达模式，重点突出整合素作为治疗和药物递送的关键靶标。接下来，描述了针对整联蛋白的治疗方法，重点是临床研究，以及基于配体的靶向药物递送策略。