Neuroimaging studies report evidence for two distinct pathophysiological models of obsessive-compulsive disorder (OCD): disrupted fronto-striatal circuits and impaired large-scale fronto-parietal-limbic intrinsic brain networks, defined by functionally connected (FC) infra-slow oscillations in ongoing brain activity. To synthesize this literature and overcome inconsistencies, we conducted a coordinate-based meta-analysis of 18 whole-brain resting-state functional magnetic resonance imaging (fMRI) studies (541 patients, 572 healthy controls) comparing seed-based FC between OCD patients and healthy controls. In patients, the meta-analysis revealed (1) consistent hypoconnectivity within frontoparietal and salience network, and between salience, frontoparietal and default-mode network, and (2) consistent general dysconnectivity (no specific direction of connectivity change) within default-mode and frontoparietal network, as well as between frontoparietal, default-mode, and salience networks. Between-network hypoconnectivity provides evidence for the triple-network model in OCD, while aberrant within-network connectivity of frontoparietal and striatal regions supports reports of aberrant fronto-striatal circuitry. Therefore, results corroborate both models of OCD pathophysiology and link them by underlining the importance of intrinsic connectivity of frontoparietal regions which are common to both models.

神经影像研究报告了强迫症（OCD）的两种不同病理生理模型的证据：额叶纹状体回路中断和大型额顶壁边缘内在性大脑网络受损，这由正在进行的功能连接（FC）红外慢振荡定义脑活动。为了综合这些文献并克服不一致之处，我们对18位全脑静止状态功能磁共振成像（fMRI）研究（541例患者，572名健康对照）进行了基于坐标的荟萃分析，比较了OCD患者和健康对照。在患者中，荟萃分析显示（1）腹膜前和腹膜显着网络之间以及腹膜显着，腹膜前和默认模式网络之间始终存在连通性低下，（2）默认模式和额顶网络之间以及额顶，默认模式和显着网络之间的一致的一般不连通性（连接的特定方向没有变化）。网络间的低连通性为OCD中的三重网络模型提供了证据，而额顶和纹状体区域的异常网络内连通性支持了异常的额体-纹状体电路的报道。因此，研究结果证实了两种强迫症病理生理模型，并通过强调这两种模型共有的额顶额叶区域内在连通性的重要性，将它们联系起来。网络间的低连通性为OCD中的三重网络模型提供了证据，而额顶和纹状体区域的异常网络内连通性支持了异常的额体-纹状体电路的报道。因此，研究结果证实了两种强迫症病理生理模型，并通过强调这两种模型共有的额顶额叶区域内在连通性的重要性，将它们联系起来。网络间的低连通性为OCD中的三重网络模型提供了证据，而额顶和纹状体区域的异常网络内连通性支持了异常的额体-纹状体电路的报道。因此，研究结果证实了两种强迫症病理生理模型，并通过强调这两种模型共有的额顶额叶区域内在连通性的重要性，将它们联系起来。