The scientific community is increasingly concerned with the proportion of published “discoveries” that are not replicated in subsequent studies. The field of rodent behavioral phenotyping was one of the first to raise this concern, and to relate it to other methodological issues: the complex interaction between genotype and environment; the definitions of behavioral constructs; and the use of laboratory mice and rats as model species for investigating human health and disease mechanisms. In January 2015, researchers from various disciplines gathered at Tel Aviv University to discuss these issues. The general consensus was that the issue is prevalent and of concern, and should be addressed at the statistical, methodological and policy levels, but is not so severe as to call into question the validity and the usefulness of model organisms as a whole. Well-organized community efforts, coupled with improved data and metadata sharing, have a key role in identifying specific problems and promoting effective solutions. Replicability is closely related to validity, may affect generalizability and translation of findings, and has important ethical implications.

科学界越来越关注未在后续研究中复制的已发表“发现”的比例。啮齿动物行为表型领域是最早提出这一问题的领域之一，并将其​​与其他方法学问题联系起来：基因型与环境之间的复杂相互作用；行为结构的定义；以及使用实验室小鼠和大鼠作为研究人类健康和疾病机制的模型物种。2015 年 1 月，来自不同学科的研究人员齐聚特拉维夫大学，讨论这些问题。普遍的共识是，这个问题很普遍，值得关注，应该在统计、方法和政策层面解决，但不会严重到质疑整个模式生物的有效性和有用性。组织良好的社区努力，加上改进的数据和元数据共享，在确定具体问题和促进有效解决方案方面发挥着关键作用。可重复性与有效性密切相关，可能影响研究结果的普遍性和翻译，并具有重要的伦理意义。