Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy.

中文翻译：

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光敏剂诱导的抗原自组装作为纳米疫苗用于癌症免疫治疗†

在本文中，光敏剂吲哚菁绿（ICG）用于诱导抗原的自组装以形成纳米疫苗。在近红外（NIR）激光照射下，纳米疫苗可产生活性氧，从而破坏内体/溶酶体的膜，从而有助于将抗原有效地释放到胞质溶胶中，从而增强抗原的交叉呈递和抗癌免疫力。据我们所知，本研究代表了ICG作为提高癌症疫苗功效的生物相容性佐剂的第一个实例。