Multifunctional antibacterial photodynamic therapy is a promising method to combat regular and multidrug‐resistant bacteria. In this work, eosin Y (EY)‐based antibacterial polycations (EY‐QEGEDR, R = CH₃ or C₆H₁₃) with versatile types of functional components including quaternary ammonium, photosensitizer, primary amine, and hydroxyl species are readily synthesized based on simple ring‐opening reactions. In the presence of light irradiation, such antibacterial polymers exhibit high antibacterial efficiency against both Escherichia coli and Staphylococcus aureus. In particular, EY‐QEGEDR elicits a remarkable synergistic antibacterial activity owing to the combined photodynamic and quaternary ammonium antibacterial effects. Due to its rich primary amine groups, EY‐QEGEDR also can be readily coated on different substrates, such as glass slides and nonwoven fabrics via an adhesive layer of polydopamine. The resultant surface coating of EY‐QEGEDCH₃ (s‐EY‐QEGEDCH₃) produces excellent in vitro antibacterial efficacy. The plentiful hydroxyl groups impart s‐EY‐QEGEDCH₃ with potential antifouling capability against dead bacteria. The antibacterial polymer coatings also demonstrate low cytotoxicity and good hemocompatibility. More importantly, s‐EY‐QEGEDCH₃ significantly enhances in vivo therapeutic effects on an infected rat model. The present work provides an efficient strategy for the rational design of high‐performance antibacterial materials to fight biomedical device‐associated infections.

中文翻译：

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具有多功能功能的聚阳离子协同抗菌剂，可有效进行抗感染治疗

多功能抗菌光动力疗法是一种对抗常规和多药耐药细菌的有前途的方法。在这项工作中，曙红Y（EY）类抗菌聚阳离子（EY-QEGED  R，R =  CH ₃或 Ç ₆ ħ ₁₃）与通用的类型的功能组件，包括季铵，光敏剂，伯胺，和羟基物种可以根据简单的开环反应轻松合成。在光辐射的存在下，这样的抗菌聚合物对大肠杆菌和金黄色葡萄球菌均显示出高的抗菌效率。特别是，EY-QEGED 由于光动力和季铵结合的抗菌作用，R引起了显着的协同抗菌活性。由于其丰富的伯胺基团，EY-QEGED  R还可以很容易地涂覆在不同的基材，例如通过聚多巴胺的粘合剂层的玻璃载片和非织造织物。的所得的表面涂层EY-QEGED  CH ₃（小号-EY-QEGED  CH ₃）产生具有优异的体外抗菌功效。丰满羟基传授小号-EY-QEGED  CH ₃具有潜在的防死细菌能力。抗菌聚合物涂层还显示出低细胞毒性和良好的血液相容性。更重要的是，š -EY-QEGED  CH ₃显著增强体内被感染大鼠模型的治疗效果。本工作为合理设计高性能抗菌材料以对抗与生物医学设备相关的感染提供了有效策略。