The marine environment is a rich source of biological and chemical diversity. It covers more than 70% of the Earth’s surface and features a wide diversity of habitats, often displaying extreme conditions, where marine organisms thrive, offering a vast pool for microorganisms and enzymes. Given the dissimilarity between marine and terrestrial habitats, enzymes and microorganisms, either novel or with different and appealing features as compared to terrestrial counterparts, may be identified and isolated. L-asparaginase (E.C. 3.5.1.1), is among the relevant enzymes that can be obtained from marine sources. This amidohydrolase acts on L-asparagine and produce L-aspartate and ammonia, accordingly it has an acknowledged chemotherapeutic application, namely in acute lymphoblastic leukemia. Moreover, L-asparaginase is also of interest in the food industry as it prevents acrylamide formation. Terrestrial organisms have been largely tapped for L-asparaginases, but most failed to comply with criteria for practical applications, whereas marine sources have only been marginally screened. This work provides an overview on the relevant features of this enzyme and the framework for its application, with a clear emphasis on the use of L-asparaginase from marine sources. The review envisages to highlight the unique properties of marine L-asparaginases that could make them good candidates for medical applications and industries, especially in food safety.

海洋环境是生物和化学多样性的丰富来源。它覆盖了地球70％以上的表面，并具有多种多样的生境，通常表现出极端条件，海洋生物在此繁衍生息，为微生物和酶提供了广阔的资源。鉴于海洋和陆地生境之间的差异，可以鉴定和分离酶和微生物，无论是新颖的还是与陆地生境相比具有不同和吸引人的特征。L-天冬酰胺酶（EC 3.5.1.1）是可以从海洋来源获得的相关酶之一。该酰胺水解酶作用于L-天冬酰胺并产生L-天冬氨酸和氨，因此其具有公认的化学治疗应用，即在急性淋巴细胞白血病中。而且，L-天冬酰胺酶在食品工业中也很重要，因为它可以防止丙烯酰胺的形成。陆生生物主要利用L-天冬酰胺酶，但大多数都没有符合实际应用标准，而海洋资源仅经过了少量筛选。这项工作概述了这种酶的相关特征及其应用框架，并明确强调了使用海洋来源的L-天冬酰胺酶。审查设想着重强调海洋L-天冬酰胺酶的独特性质，使其可以成为医学应用和工业特别是食品安全领域的良好候选者。而仅对海洋资源进行了少量筛选。这项工作概述了这种酶的相关特征及其应用框架，并明确强调了使用海洋来源的L-天冬酰胺酶。审查设想着重强调海洋L-天冬酰胺酶的独特性质，使其可以成为医学应用和工业特别是食品安全领域的良好候选者。而仅对海洋资源进行了少量筛选。这项工作概述了这种酶的相关特征及其应用框架，并明确强调了使用海洋来源的L-天冬酰胺酶。审查设想着重强调海洋L-天冬酰胺酶的独特性质，使其可以成为医学应用和工业特别是食品安全领域的良好候选者。