The intrinsic properties of therapeutic proteins generally present a major impediment for transdermal delivery, including their relatively large molecule size and susceptibility to degradation. One solution is to utilize microneedles (MNs), which are capable of painlessly traversing the stratum corneum and directly translocating protein drugs into the systematic circulation. MNs can be designed to incorporate appropriate structural materials as well as therapeutics or formulations with tailored physicochemical properties. This platform technique has been applied to deliver drugs both locally and systemically in applications ranging from vaccination to diabetes and cancer therapy. This review surveys the current design and use of polymeric MNs for transdermal protein delivery. The clinical potential and future translation of MNs are also discussed.

治疗性蛋白质的内在性质通常是透皮递送的主要障碍，包括其相对较大的分子大小和降解敏感性。一种解决方案是利用微针（MNs），它们能够无痛地穿越角质层并将蛋白药物直接转移到系统循环中。MN可以设计为包含适当的结构材料以及具有定制理化特性的治疗剂或制剂。该平台技术已被应用于从疫苗接种到糖尿病和癌症治疗等领域的局部和全身性给药。这篇综述调查了聚合物MN用于透皮蛋白递送的当前设计和使用。还讨论了MN的临床潜力和未来翻译。