S_NAr reaction on DNMTs: Oligodeoxyribonucleotides containing 2‐amino‐4‐halopyridine‐C‐nucleosides (d^XP) at the CpG site form a covalent complex with DNA cytosine‐5 methyltransferases (DNMTs) through a nucleophilic aromatic substitution (S_NAr) reaction. DNA containing d^XP in a CpG sequence could be a useful chemical probe for studies of epigenetics and a potential nucleic acid drug lead in cancer chemotherapy.

中文翻译：

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基于机制的DNA胞嘧啶5甲基转移酶抑制剂通过SNAr反应与包含2-氨基-4-卤代吡啶-C-核苷的寡脱氧核糖核苷酸的反应

小号_Ñ上转移酶的Ar反应：含有寡脱氧核糖核苷酸的2-氨基-4- halopyridine- Ç核苷（d ^X P）在CpG位点形成复合物与DNA胞嘧啶-5-甲基转移酶（转移酶）通过亲核芳族取代的共价（S _Ñ Ar）反应。CpG序列中含有d ^X P的DNA可能是用于研究表观遗传学的有用化学探针，并可能成为癌症化学疗法中潜在的核酸药物。