NDP52/CALCOCO2 makes multiple contributions to selective autophagy. By interacting with cargos and LC3, NDP52 directs autophagy targets to autophagosomes. In addition, NDP52 promotes autophagosomes fusion with endolysosomes by connecting autophagosomes to MYOSIN VI. Recent studies reveal that Rab35 GTPase controls NDP52 recruitment to its targets and that NDP52 triggers MYOSIN VI (MYO6) motility.

中文翻译：

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NDP52自噬受体功能的新颖见解。

NDP52 / CALCOCO2为选择性自噬做出了多种贡献。通过与货物和LC3相互作用，NDP52将自噬靶标导向自噬体。另外，NDP52通过将自噬小体连接到MYOSIN VI上来促进自噬小体与内溶体的融合。最近的研究表明，Rab35 GTPase可控制NDP52募集至其靶标，并且NDP52触发MYOSIN VI（MYO6）运动。