The aim of this retrospective study was to compare the heart-to-mediastinum ratio (HMR) of ¹²³I-metaiodobenzylguanidine (¹²³I-MIBG) uptake obtained using a multipinhole cadmium–zinc–telluride (CZT) camera with that obtained using conventional planar imaging. Methods: Forty consecutive heart failure patients underwent planar acquisition 4 h after ¹²³I-MIBG injection (191 ± 41 [mean ± SD] MBq). To localize the heart using the CZT camera, ^99mTc-tetrofosmin (358 ± 177 MBq) was administered and dual-isotope acquisition was performed. The HMRs were calculated with conventional planar imaging (HMR_planar), with anterior reprojection images using the CZT camera (HMR_reproj), and with transaxial reconstructed images using the CZT camera (HMR_transaxial). In a phantom study, we estimated a linear model fitting the CZT camera data to the planar data, and we applied it to provide corrected CZT camera–determined HMRs in patients (cHMR_reproj and cHMR_transaxial). Results: Thirty-four men and 6 women (71 ± 9 y old) with ischemic (22 patients) and nonischemic (18 patients) heart failure completed the study. For 22 of the 40 patients (55%), the New York Heart Association classification was class II and the ejection fraction was 35% ± 9%. HMR_reproj (1.12 ± 0.19) and HMR_transaxial (1.35 ± 0.34) were lower than HMR_planar (1.44 ± 0.14) (P < 0.0001 and P < 0.01, respectively). cHMR_reproj (1.54 ± 0.09) and cHMR_transaxial (1.45 ± 0.14) were significantly different (P < 0.0001). Lin concordance correlation and Bland–Altman analysis demonstrated an almost perfect concordance and a high agreement between HMR_planar and cHMR_transaxial (P was not significant) but not between HMR_planar and cHMR_reproj (P < 0.0001). Conclusion: This study demonstrated that determination of the late HMR of cardiac ¹²³I-MIBG uptake using dual-isotope (¹²³I and ^99mTc) acquisition on a multipinhole CZT camera was feasible in patients with heart failure. However, this determination should be performed using transaxial reconstructed images and linear correction based on phantom data acquisitions.

这项回顾性研究的目的是比较使用多针孔镉锌锌碲化物（CZT）相机获得的¹²³ I-蛋氨酸苄基胍（¹²³ I-MIBG）摄取的心脏与纵隔之比（HMR）与使用传统平面成像。方法： 40例连续性心力衰竭患者在¹²³ I-MIBG注射后（191±41 [mean±SD] MBq）进行了4 h平面获取。为了使用CZT摄像机对心脏进行定位，需要施用^99m Tc-四氟膦（358±177 MBq），并进行双同位素采集。所述HMRS用常规平面成像（HMR计算_平面），在使用相机CZT前重投影图像（HMR _reproj），以及使用CZT相机（HMR _transaxial）进行跨轴重建的图像。在体模研究中，我们估计一个线性模型拟合CZT相机数据到平面数据，并且我们将其运用以提供校正的CZT相机确定的HMRS患者（cHMR _reproj和cHMR_横断）。结果：患有缺血性心力衰竭（22例）和非缺血性心力衰竭（18例）的三十四名男性和六名女性（71±9岁）完成了研究。对于40名患者中的22名（55％），纽约心脏协会的分类为II级，射血分数为35％±9％。HMR _reproj（1.12±0.19）和HMR_跨轴（1.35±0.34）低于HMR_平面（1.44±0.14）（分别为P <0.0001和P <0.01）。cHMR _reproj（1.54±0.09）和cHMR跨_轴（1.45±0.14）有显着差异（P <0.0001）。Lin一致性相关性和Bland-Altman分析表明，HMR_平面与cHMR跨_轴之间几乎完美的一致性和高度一致性（P不显着），而HMR_平面与cHMR _reproj之间却没有_一致性（P <0.0001）。结论：这项研究表明，使用双同位素（^123）可确定心脏¹²³ I-MIBG摄取的晚期HMR。在多针孔CZT相机上采集I和^99m Tc）在心力衰竭患者中是可行的。但是，应该使用跨轴重构图像和基于幻像数据采集的线性校正来执行此确定。