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The Basal Forebrain Regulates Global Resting-State fMRI Fluctuations.
Neuron ( IF 16.2 ) Pub Date : 2018-02-01 , DOI: 10.1016/j.neuron.2018.01.032
Janita Turchi 1 , Catie Chang 2 , Frank Q Ye 3 , Brian E Russ 1 , David K Yu 3 , Carlos R Cortes 4 , Ilya E Monosov 5 , Jeff H Duyn 2 , David A Leopold 6
Affiliation  

Patterns of spontaneous brain activity, typically measured in humans at rest with fMRI, are used routinely to assess the brain's functional organization. The mechanisms that generate and coordinate the underlying neural fluctuations are largely unknown. Here we investigate the hypothesis that the nucleus basalis of Meynert (NBM), the principal source of widespread cholinergic and GABAergic projections to the cortex, contributes critically to such activity. We reversibly inactivated two distinct sites of the NBM in macaques while measuring fMRI activity across the brain. We found that inactivation led to strong, regionalized suppression of shared or "global" signal components of cortical fluctuations ipsilateral to the injection. At the same time, the commonly studied resting-state networks retained their spatial structure under this suppression. The results indicate that the NBM contributes selectively to the global component of functional connectivity but plays little if any role in the specific correlations that define resting-state networks.

中文翻译:

基底前脑调节整体静息状态 fMRI 波动。

自发性大脑活动的模式通常用于评估大脑的功能组织,通常使用 fMRI 在人类静止时测量。产生和协调潜在神经波动的机制在很大程度上是未知的。在这里,我们研究了 Meynert 基底核 (NBM) 的假设,它是广泛的胆碱能和 GABA 能投射到皮质的主要来源,对这种活动有重要贡献。我们在测量整个大脑的 fMRI 活动时,可逆地灭活了猕猴 NBM 的两个不同位点。我们发现失活导致对注射同侧皮质波动的共享或“全局”信号成分的强烈、区域化抑制。同时,通常研究的静息态网络在这种抑制下保留了它们的空间结构。结果表明,NBM 有选择地对功能连接的全局组成部分做出贡献,但在定义静息状态网络的特定相关性中几乎没有任何作用。
更新日期:2018-02-01
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