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Ultra-Slow Single-Vessel BOLD and CBV-Based fMRI Spatiotemporal Dynamics and Their Correlation with Neuronal Intracellular Calcium Signals.
Neuron ( IF 16.2 ) Pub Date : 2018-Feb-21 , DOI: 10.1016/j.neuron.2018.01.025
Yi He 1 , Maosen Wang 1 , Xuming Chen 1 , Rolf Pohmann 2 , Jonathan R Polimeni 3 , Klaus Scheffler 4 , Bruce R Rosen 3 , David Kleinfeld 5 , Xin Yu 2
Affiliation  

Functional MRI has been used to map brain activity and functional connectivity based on the strength and temporal coherence of neurovascular-coupled hemodynamic signals. Here, single-vessel fMRI reveals vessel-specific correlation patterns in both rodents and humans. In anesthetized rats, fluctuations in the vessel-specific fMRI signal are correlated with the intracellular calcium signal measured in neighboring neurons. Further, the blood-oxygen-level-dependent (BOLD) signal from individual venules and the cerebral-blood-volume signal from individual arterioles show correlations at ultra-slow (<0.1 Hz), anesthetic-modulated rhythms. These data support a model that links neuronal activity to intrinsic oscillations in the cerebral vasculature, with a spatial correlation length of ∼2 mm for arterioles. In complementary data from awake human subjects, the BOLD signal is spatially correlated among sulcus veins and specified intracortical veins of the visual cortex at similar ultra-slow rhythms. These data support the use of fMRI to resolve functional connectivity at the level of single vessels.

中文翻译:

基于超慢单血管 BOLD 和 CBV 的 fMRI 时空动力学及其与神经元细胞内钙信号的相关性。

功能性 MRI 已用于根据神经血管耦合血流动力学信号的强度和时间相干性来绘制大脑活动和功能连接图。在这里,单血管功能磁共振成像揭示了啮齿动物和人类的血管特异性相关模式。在麻醉大鼠中,血管特异性功能磁共振成像信号的波动与邻近神经元中测量的细胞内钙信号相关。此外,来自各个小静脉的血氧水平依赖性(BOLD)信号和来自各个小动脉的脑血容量信号在超慢(<0.1 Hz)麻醉调节节律下显示出相关性。这些数据支持一个模型,该模型将神经元活动与脑血管系统的内在振荡联系起来,小动脉的空间相关长度为~2毫米。在来自清醒人类受试者的补充数据中,BOLD 信号在沟静脉和视觉皮层的特定皮质内静脉之间以类似的超慢节奏存在空间相关性。这些数据支持使用功能磁共振成像来解决单血管水平的功能连接问题。
更新日期:2018-02-01
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