Image-guided and target-selective modulation of drug delivery by external physical triggers at the site of pathology has the potential to enable tailored control of drug targeting. Magnetic microbubbles that are responsive to magnetic and acoustic modulation and visible to ultrasonography have been proposed as a means to realize this drug targeting strategy. To comply with this strategy in vivo, magnetic microbubbles must circulate systemically and evade deposition in pulmonary capillaries, while also preserving magnetic and acoustic activities in circulation over time. Unfortunately, challenges in fabricating magnetic microbubbles with such characteristics have limited progress in this field. In this report, we develop magnetic microbubbles (MagMB) that display strong magnetic and acoustic activities, while also preserving the ability to circulate systemically and evade pulmonary entrapment.

中文翻译：

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循环磁微泡通过超声引导下的磁性靶向和超声对药物输送进行局部实时控制

通过病理部位外部物理触发物对药物输送的图像引导和靶点选择性调节，有可能实现对药物靶向的定制控制。已经提出了响应于磁和声调制并且对超声检查可见的磁性微泡作为实现这种药物靶向策略的手段。为了在体内遵守这一策略，磁性微气泡必须在循环中循环并避免在肺毛细血管中沉积，同时还必须随着时间的流逝保持磁性和声学活动。不幸的是，制造具有这种特性的磁性微气泡的挑战限制了该领域的进展。在本报告中，我们开发了显示出强大的磁和声活动的磁性微气泡（MagMB），同时还保留了系统循环和逃避肺部夹带的能力。