Purpose: In this study, we report the design, development and evaluation of a hollow drug delivery nanoplatform for cancer therapy in vitro and in vivo. This composite nanosystem was prepared by modifying hollow mesoporous silica nanoparticles (HMSNs) with transferrin (Tf) targeting moieties via redox-liable linkage, and was capable of delivering therapeutic cargos (doxorubicin) specifically to the tumor site and subsequently releasing them in an on-demand manner. Moreover, the Tf corona could simultaneously reduce the inflammatory response after intravenous administration in vivo.

中文翻译：

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一种转铁蛋白共轭空心纳米平台，用于肿瘤的氧化还原控制和靶向化疗，并减少炎症反应

目的：在本研究中，我们报告了用于体外和体内癌症治疗的中空药物递送纳米平台的设计、开发和评估。这种复合纳米系统是通过修饰中空介孔二氧化硅纳米粒子（HMSNs）与转铁蛋白（Tf）靶向部分通过氧化还原键连接而制备的，并且能够将治疗性货物（多柔比星）特异性递送至肿瘤部位并随后将它们释放到肿瘤部位。需求方式。此外，Tf corona 可以同时降低体内静脉给药后的炎症反应。