Rationale: Phagocytosis of silicon dioxide (SiO₂) into lung cells causes an inflammatory cascade that results in fibroblast proliferation and migration, followed by fibrosis. Circular RNAs (circRNAs) are a subclass of non-coding RNAs detected within mammalian cells; however, researchers have not determined whether circRNAs are involved in the pathophysiological process of silicosis. The upstream molecular mechanisms and functional effects on cell apoptosis, proliferation and migration were investigated to elucidate the role of circRNAs in SiO₂-induced inflammation in pulmonary macrophages.

中文翻译：

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circRNA 通过 HECTD1/ZC3H12A 依赖性泛素化介导二氧化硅诱导的巨噬细胞活化

基本原理：二氧化硅 (SiO ₂ ) 吞噬到肺细胞中会引起炎症级联反应，导致成纤维细胞增殖和迁移，然后是纤维化。环状 RNA (circRNA) 是在哺乳动物细胞内检测到的非编码 RNA 的一个子类；然而，研究人员尚未确定 circRNA 是否参与矽肺的病理生理过程。研究了细胞凋亡、增殖和迁移的上游分子机制和功能影响，以阐明circRNA在SiO ₂诱导的肺巨噬细胞炎症中的作用。