Cytoskeletal networks are dramatically reorganized upon EGF stimulation to enable complex cell behaviors such as cell-cell communication, migration and invasion, and cell division. In this issue of Science Signaling, Roth et al. and Pike et al. use proteomic methods to identify several effectors of EGF responses. The findings show the interdependent nature of growth factor signaling and the cytoskeleton and identify potential new therapeutic targets for treating cancer and other growth factor–driven diseases.

中文翻译：

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EGFR诱导的细胞骨架变化驱动复杂的细胞行为：冰山一角

在EGF刺激下，细胞骨架网络得到了显着重组，以实现复杂的细胞行为，例如细胞间通讯，迁移和侵袭以及细胞分裂。在本期《科学信号》中，Roth等人。和派克等。使用蛋白质组学方法来鉴定EGF反应的几种效应子。研究结果表明生长因子信号传导和细胞骨架具有相互依存的性质，并确定了治疗癌症和其他生长因子驱动的疾病的潜在新治疗靶标。