The human innate immune system launches a metal-withholding response to starve invading microbial pathogens of essential metal nutrients. Zn(II)-sequestering proteins of the human S100 family contribute to this process and include calprotectin (CP, S100A8/S100A9 oligomer, calgranulin A/B oligomer), S100A12 (calgranulin C), and S100A7 (psoriasin). This Perspective highlights recent advances in the Zn(II) coordination chemistry of these three proteins, as well as select studies that evaluate Zn(II) sequestration as an antimicrobial mechanism.

中文翻译：

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人类S100宿主防御蛋白螯合Zn（II）的生物无机探索

人类的先天免疫系统会发出一种金属扣留反应，以使必需金属养分的入侵微生物病原体饥饿。人S100家族的Zn（II）替代蛋白对此过程做出了贡献，包括钙卫蛋白（CP，S100A8 / S100A9低聚物，钙粒蛋白A / B寡聚物），S100A12（钙粒蛋白C）和S100A7（psoriasin）。该观点着重介绍了这三种蛋白质的Zn（II）配位化学的最新进展，以及将Zn（II）螯合作为一种抗菌机制进行评估的精选研究。