Nanostructured polyion complexes (PICs) are expected to serve as novel platforms to stabilize and deliver drugs, proteins, and nucleic acids. Yet, traditional self-assembly suffers from lack of scale-up and reproducibility. Particularly for one-component PICs, only spheres are available to date. Here, we report an efficient and scalable strategy to prepare one-component low-dimensional PICs. It involves visible-light-mediated RAFT iterative polymerization of opposite-charge monomers at 25% w/w solids in water at 25 °C. Sphere-film-vesicle transition and charge-/medium-tunable shape selectivity are reported. One-component PIC nanowire, ultrathin film, vesicle, tube, and surface-charged vesicle are easily prepared, and vesicle-polymerization is fulfilled, using this new strategy. This strategy provides a general platform to prepare one-component low-dimensional PICs with tailorable morphologies and high reproducibility on commercially viable scale under eco-friendly conditions.

中文翻译：

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聚合诱导静电自组装合成单组分纳米结构聚离子配合物

纳米结构的聚离子复合物 (PIC) 有望成为稳定和输送药物、蛋白质和核酸的新平台。然而，传统的自组装缺乏放大和可重复性。特别是对于单组分 PIC，迄今为止只有球体可用。在这里，我们报告了一种有效且可扩展的策略来准备单分量低维 PIC。它涉及在 25 °C 的水中以 25% w/w 的固体在可见光介导的反电荷单体的 RAFT 迭代聚合。报告了球-膜-囊泡转变和电荷/介质可调形状选择性。使用这种新策略，可以轻松制备单组分 PIC 纳米线、超薄膜、囊泡、管和表面带电囊泡，并实现囊泡聚合。