In order to maintain a smooth optical surface the corneal epithelium has to continuously renew itself so as to maintain its function as a barrier to fluctuating external surroundings and various environmental insults. After trauma, the cornea typically re-epithelializes promptly thereby minimizing the risk of infection, opacification or perforation. A persistent epithelial defect (PED) is usually referred to as a non-healing epithelial lesion after approximately two weeks of treatment with standard therapies to no avail. They occur following exposure to toxic agents, mechanical injury, and ocular surface infections and are associated with significant clinical morbidity in patients, resulting in discomfort or visual loss. In the case of deeper corneal injury and corneal pathology the wound healing cascade can also extend to the corneal stroma, the layer below the epithelium. Although significant progress has been made in recent years, pharmaco-therapeutic agents that promote corneal healing remain limited. This article serves as a review of current standard therapies, recently introduced alternative therapies gaining in popularity, and a look into the newest developments into ocular wound healing.

为了维持光滑的光学表面，角膜上皮必须不断地自我更新，以保持其功能，以作为对周围环境和各种环境损害的波动的屏障。创伤后，角膜通常会迅速重新上皮化，从而将感染，浑浊或穿孔的风险降至最低。持续性上皮缺损（PED）通常被称为无治愈的上皮病变，经过约两周的标准疗法治疗均无济于事。它们在暴露于有毒物质，机械损伤和眼表感染后发生，并与患者显着的临床发病率相关，从而导致不适或视力丧失。在更深的角膜损伤和角膜病理的情况下，伤口愈合的阶梯也可以延伸到角膜基质，上皮下面的层。尽管近年来已经取得了重大进展，但是促进角膜愈合的药物治疗剂仍然有限。本文是对当前标准疗法的综述，最近介绍了越来越流行的替代疗法，并探讨了眼部伤口愈合的最新进展。