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A Numerical model of exchange chromatography through 3‐D lattice structures
AIChE Journal ( IF 3.7 ) Pub Date : 2018-02-22 , DOI: 10.1002/aic.16108
Maher Salloum 1 , David B. Robinson 1
Affiliation  

Rapid progress in the development of additive manufacturing technologies is opening new opportunities to fabricate structures that control mass transport in three dimensions across a broad range of length scales. We describe a structure that can be fabricated by newly available commercial 3‐D printers. It contains an array of regular three‐dimensional flow paths that are in intimate contact with a solid phase, and thoroughly shuffle material among the paths. We implement a chemically reacting flow model to study its behavior as an exchange chromatography column, and compare it to an array of 1‐D flow paths that resemble more traditional honeycomb monoliths. A reaction front moves through the columns and then elutes. The front is sharper at all flow rates for the structure with three‐dimensional flow paths, and this structure is more robust to channel width defects than the 1‐D array. © 2018 American Institute of Chemical Engineers AIChE J, 64: 1874–1884, 2018

中文翻译:

通过3-D晶格结构进行交换色谱的数值模型

增材制造技术发展的快速进步为制造可在大范围的长度范围内三维控制质量传输的结构提供了新的机遇。我们描述了可以由新的商用3D打印机制造的结构。它包含规则的三维流路阵列,这些流路与固相紧密接触,并在流路中彻底混洗材料。我们实现了一个化学反应流模型,以研究其作为交换色谱柱的行为,并将其与一维类似于传统蜂窝状整体结构的一维流路进行比较。反应前沿穿过色谱柱,然后洗脱。对于具有三维流路的结构,在所有流速下,前端都更加锋利,与一维阵列相比,这种结构对通道宽度缺陷的鲁棒性更高。©2018美国化学工程师学会AIChE J,64:1874–1884,2018
更新日期:2018-02-22
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