Elevation in iron content as well as severe depletion of dopamine (DA) as a result of iron-induced loss of dopaminergic neurons has been recognized to accompany the progression of Parkinson’s disease (PD). To better understand the mechanism of the mitigating effect of the iron chelator deferiprone (DFP) on PD, the interplay between iron and DFP was investigated both in the absence and presence of DA. The results show that DFP was extremely efficient in scavenging both aqueous iron and iron that was loosely bound to DA with the entrapment of iron in Fe-DFP complexed form critical to halting the iron catalyzed degradation of DA and associated generation of toxic metabolites. The DFP related scavenging of dopamine semiquinone (DA^•–) and superoxide (O₂^•–) may also contribute to its positive effects in the treatment of PD.

中文翻译：

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去铁酮缓解帕金森氏病症状的基本机制

铁引起的多巴胺能神经元的丧失导致铁含量的升高以及多巴胺（DA）的严重耗竭已被认为与帕金森氏病（PD）的进展有关。为了更好地了解铁螯合剂去铁酮（DFP）减轻PD的作用机理，在不存在和存在DA的情况下，研究了铁和DFP之间的相互作用。结果表明，DFP在清除铁水溶液中的铁和与铁松散结合的铁方面非常有效，铁以Fe-DFP络合物形式截留，对停止铁催化的DA降解和相关的有毒代谢产物的生成至关重要。DFP清除多巴胺半醌（DA ^•–）和超氧化物（O ₂ ^•–）也可能有助于其在PD治疗中发挥积极作用。