Electrospun nanofibers possess an extremely large surface area to volume ratio, good biocompatibility, ability to mimic native extracellular matrix, and the advantages of easy preparation and surface functionalization. These properties enable them to be used as an ideal platform for cancer cell capture applications. This review reports some recent advances in the use of nanofibers for cancer cell capture applications, in particular, preparation and surface functionalization of nanofibers with targeting molecules, static capture of cancer cells using nanofibrous substrates, dynamic capture of cancer cells and circulating tumor cells using fiber-integrated microfluidic platforms, and strategies used to release the captured cancer cells. Some of the key developments are introduced and summarized in detail; future perspectives are also briefly discussed.

中文翻译：

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用于癌细胞捕获应用的功能性电纺纳米纤维的设计

电纺纳米纤维具有极大的表面积体积比，良好的生物相容性，模仿天然细胞外基质的能力以及易于制备和表面功能化的优点。这些特性使它们可以用作癌细胞捕获应用程序的理想平台。这篇综述报道了纳米纤维在癌细胞捕获应用中的一些最新进展，特别是具有靶向分子的纳米纤维的制备和表面功能化，使用纳米纤维基质静态捕获癌细胞，动态捕获癌细胞以及使用纤维循环肿瘤细胞集成的微流体平台，以及用于释放捕获的癌细胞的策略。对一些关键的发展进行了介绍和详细总结；