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Lytic xylan oxidases from wood-decay fungi unlock biomass degradation
Nature Chemical Biology ( IF 14.8 ) Pub Date : 2018-01-29 , DOI: 10.1038/nchembio.2558
Marie Couturier , Simon Ladevèze , Gerlind Sulzenbacher , Luisa Ciano , Mathieu Fanuel , Céline Moreau , Ana Villares , Bernard Cathala , Florence Chaspoul , Kristian E Frandsen , Aurore Labourel , Isabelle Herpoël-Gimbert , Sacha Grisel , Mireille Haon , Nicolas Lenfant , Hélène Rogniaux , David Ropartz , Gideon J Davies , Marie-Noëlle Rosso , Paul H Walton , Bernard Henrissat , Jean-Guy Berrin

Wood biomass is the most abundant feedstock envisioned for the development of modern biorefineries. However, the cost-effective conversion of this form of biomass into commodity products is limited by its resistance to enzymatic degradation. Here we describe a new family of fungal lytic polysaccharide monooxygenases (LPMOs) prevalent among white-rot and brown-rot basidiomycetes that is active on xylans—a recalcitrant polysaccharide abundant in wood biomass. Two AA14 LPMO members from the white-rot fungus Pycnoporus coccineus substantially increase the efficiency of wood saccharification through oxidative cleavage of highly refractory xylan-coated cellulose fibers. The discovery of this unique enzyme activity advances our knowledge on the degradation of woody biomass in nature and offers an innovative solution for improving enzyme cocktails for biorefinery applications.



中文翻译:

木材腐烂真菌中的木聚糖氧化酶可解除生物质降解

木材生物质是用于现代生物精炼厂发展的最丰富的原料。然而,这种形式的生物质向商品产品的经济有效转化受到其对酶促降解的抵抗性的限制。在这里,我们描述了一个新的真菌溶菌多糖单加氧酶(LPMO)家族,在白腐和棕腐担子菌中普遍存在,对木聚糖具有活性-木糖是一种顽固的多糖,木材生物量丰富。白腐真菌Pycnoporus coccineus的两个AA14 LPMO成员通过高耐性木聚糖涂层纤维素纤维的氧化裂解,大大提高了木材的糖化效率。这种独特酶活性的发现提高了我们对自然界中木质生物质降解的认识,并为改善用于生物精炼应用的酶混合物提供了创新的解决方案。

更新日期:2018-01-30
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