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The systemic toxicity of heavy metal mixtures in rats
Toxicology Research ( IF 2.1 ) Pub Date : 2018-01-29 00:00:00 , DOI: 10.1039/c7tx00260b
Samuel Selorm Fiati Kenston 1, 2, 3, 4, 5 , Hong Su 1, 2, 3, 4, 5 , Zhou Li 1, 2, 3, 4, 5 , Lu Kong 6, 7, 8, 9, 10 , Yafei Wang 1, 2, 3, 4, 5 , Xin Song 1, 2, 3, 4, 5 , Yuanliang Gu 1, 2, 3, 4, 5 , Tabatha Barber 11, 12, 13, 14, 15 , Joni Aldinger 11, 12, 13, 14, 15 , Qihang Hua 1, 2, 3, 4, 5 , Zhen Li 1, 2, 3, 4, 5 , Min Ding 11, 12, 13, 14, 15 , Jinshun Zhao 1, 2, 3, 4, 5 , Xialu Lin 1, 2, 3, 4, 5
Affiliation  

To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). The eight most common detectable heavy metals in Ningbo area are zinc (Zn), copper (Cu), manganese (Mn), chromium (Cr), nickel (Ni), cadmium (Cd), lead (Pb) and mercury (Hg). In this study, mixtures of these eight heavy metals were prepared using the compounds zinc sulfate heptahydrate, cupric sulfate, manganese dichloride, potassium dichromate, nickel dichloride, cadmium dichloride, lead acetate, and methyl mercury chloride with ion mass proportions of 1070.0, 312.6, 173.1, 82.6, 30.0, 13.3, 6.6, and 1.0, respectively. The rats were randomly divided into four groups. Beside the control group, each rat received a corresponding dose of HMMs 215, 464 or 1000 mg per kg body weight (bwt), respectively. The rats were observed for 4 weeks. During the last week of observation, the Morris water maze test was used to investigate spatial learning and memory in the treated rats. The rats were exsanguinated under complete chloral hydrate anesthesia and organ coefficients were measured. Biochemical tests of blood and serum samples were carried out. The results showed abnormalities in the hematological system, decreased renal function, hepatic injury and disturbances in the electrolyte balance of the rats treated with a high dose of HMMs. Death of some rats was also observed. This paper analyzed how a one-time high dose oral administration of HMMs induced systemic toxicity.

中文翻译:

重金属混合物对大鼠的全身毒性

为了探讨多重金属暴露对健康的影响,给Sprague Dawley(SD)大鼠口服一剂重金属混合物(HMM)。宁波地区最常见的八种可检测到的重金属是锌(Zn),铜(Cu),锰(Mn),铬(Cr),镍(Ni),镉(Cd),铅(Pb)和汞(Hg) 。在这项研究中,使用七水合硫酸锌,硫酸铜,二氯化锰,重铬酸钾,二氯化镍,二氯化镉,乙酸铅和甲基氯化汞制备了八种重金属的混合物,离子质量比为1070.0、312.6,分别为173.1、82.6、30.0、13.3、6.6和1.0。将大鼠随机分为四组。除对照组外,每只大鼠分别接受相应剂量的HMM 215、464或1000 mg / kg体重(bwt)。观察大鼠4周。在观察的最后一周,莫里斯水迷宫测试用于研究治疗大鼠的空间学习和记忆。在完全水合氯醛麻醉下将大鼠放血,并测量器官系数。进行血液和血清样品的生化测试。结果显示,用高剂量HMM治疗的大鼠血液系统异常,肾功能下降,肝损伤和电解质平衡紊乱。还观察到一些大鼠的死亡。本文分析了一次高剂量口服HMMs如何引起全身毒性。在完全水合氯醛麻醉下将大鼠放血,并测量器官系数。进行血液和血清样品的生化测试。结果显示,用高剂量HMM治疗的大鼠血液系统异常,肾功能下降,肝损伤和电解质平衡紊乱。还观察到一些大鼠的死亡。本文分析了一次高剂量口服HMMs如何引起全身毒性。在完全水合氯醛麻醉下将大鼠放血,并测量器官系数。进行血液和血清样品的生化测试。结果显示,用高剂量HMM治疗的大鼠血液系统异常,肾功能下降,肝损伤和电解质平衡紊乱。还观察到一些大鼠的死亡。本文分析了一次高剂量口服HMMs如何引起全身毒性。还观察到一些大鼠的死亡。本文分析了一次高剂量口服HMMs如何引起全身毒性。还观察到一些大鼠的死亡。本文分析了一次高剂量口服HMMs如何引起全身毒性。
更新日期:2018-01-29
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