The recent discovery of CRISPR and its application as a gene editing tool has enabled a range of gene drive systems to be engineered with greater ease. In order for the benefits of this technology to be realized, in some circumstances drive systems should be developed that are capable of both spreading into populations to achieve their desired impact and being recalled in the event of unwanted consequences or public disfavor. We review the performance of three broad categories of drive systems at achieving these goals: threshold-dependent drives, homing-based drive and remediation systems, and temporally self-limiting systems such as daisy-chain drives.

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基于 CRISPR 的基因驱动可以在野外进行限制吗？分子和群体生物学的一个问题

最近发现的 CRISPR 及其作为基因编辑工具的应用使得一系列基因驱动系统的设计变得更加容易。为了实现这项技术的好处，在某些情况下，应该开发出既能够传播到人群中以实现其预期影响，又能够在出现不良后果或公众不喜欢时被召回的驱动系统。我们回顾了三大类驱动系统在实现这些目标方面的性能：阈值相关驱动器、基于归位的驱动器和修复系统以及菊花链驱动器等临时自限制系统。