Abstract

A new copper-catalyzed intermolecular 1,2-aminoalkylation of alkenes with α-bromoalkyl esters and amines for the synthesis of γ-amino esters is described. Employing the Cu(OTf)₂ and 2,2′-bipyridine catalytic system, the three-component reaction allows the formation of two new chemical bonds, including one C–C bond and one C–N bond, in a single reaction, and represents a new alkene difunctionalization using a radical strategy.

A new copper-catalyzed intermolecular 1,2-aminoalkylation of alkenes with α-bromoalkyl esters and amines for the synthesis of γ-amino esters is described. Employing the Cu(OTf)₂ and 2,2′-bipyridine catalytic system, the three-component reaction allows the formation of two new chemical bonds, including one C–C bond and one C–N bond, in a single reaction, and represents a new alkene difunctionalization using a radical strategy.

中文翻译：

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铜与胺和α-溴代烷基酯的铜催化烯烃间的1,2-氨基烷基化反应合成γ-氨基酯

摘要

描述了一种新的铜催化的烯烃与α-溴代烷基酯和胺的分子间1,2-氨基烷基化反应，用于合成γ-氨基酯。利用Cu（OTf）₂和2,2'-联吡啶催化体系，三组分反应可以在一个反应​​中形成两个新的化学键，包括一个CC键和一个CN键。代表使用自由基策略的新烯烃双官能化。

描述了一种新的铜催化的烯烃与α-溴代烷基酯和胺的分子间1,2-氨基烷基化反应，用于合成γ-氨基酯。利用Cu（OTf）₂和2,2'-联吡啶催化体系，三组分反应可以在一个反应​​中形成两个新的化学键，包括一个CC键和一个CN键。代表使用自由基策略的新烯烃双官能化。