当前位置: X-MOL 学术Ann. Review Paleopathol. Mech. Disease › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology
Annual Review of Pathology: Mechanisms of Disease ( IF 36.2 ) Pub Date : 2018-01-24 00:00:00 , DOI: 10.1146/annurev-pathol-020117-044010
Jacquelyn O. Russell 1 , Satdarshan P. Monga 1, 2, 3
Affiliation  

The liver is an organ that performs a multitude of functions, and its health is pertinent and indispensable to survival. Thus, the cellular and molecular machinery driving hepatic functions is of utmost relevance. The Wnt signaling pathway is one such signaling cascade that enables hepatic homeostasis and contributes to unique hepatic attributes such as metabolic zonation and regeneration. The Wnt/β-catenin pathway plays a role in almost every facet of liver biology. Furthermore, its aberrant activation is also a hallmark of various hepatic pathologies. In addition to its signaling function, β-catenin also plays a role at adherens junctions. Wnt/β-catenin signaling also influences the function of many different cell types. Due to this myriad of functions, Wnt/β-catenin signaling is complex, context-dependent, and highly regulated. In this review, we discuss the Wnt/β-catenin signaling pathway, its role in cell-cell adhesion and liver function, and the cell type–specific roles of Wnt/β-catenin signaling as it relates to liver physiology and pathobiology.

中文翻译:


Wnt /β-Catenin信号传导在肝脏发育,体内平衡和病理生物学中的作用

肝脏是执行多种功能的器官,其健康与生存息息相关且不可或缺。因此,驱动肝功能的细胞和分子机械是最重要的。Wnt信号传导途径是一种这样的信号传导级联,其​​能够实现肝脏稳态,并有助于独特的肝脏特性,例如代谢区带和再生。Wnt /β-catenin途径几乎在肝生物学的每个方面都起作用。此外,其异常激活也是各种肝病理学的标志。除其信号传导功能外,β-连环蛋白还在粘附连接处发挥作用。Wnt /β-catenin信号传导也影响许多不同细胞类型的功能。由于具有多种功能,Wnt /β-catenin信号传导是复杂的,取决于上下文的,并且受到高度调控。在这篇评论中,

更新日期:2018-01-24
down
wechat
bug