Propyl paraben is a widely used preservative in pharmaceuticals, cosmetics, and foods preventing microbial and fungal contamination. This study was designed to investigate antiandrogenic profiles of propyl paraben following oral doses at 10, 250, and 750 mg kg⁻¹ day to immature male rats using the Hershberger Bioassay. Rats were divided into six groups including solvent control, negative control (0.4 mg kg⁻¹ day testosterone propionate = TP), positive control (3 mg kg⁻¹ day flutamide = FLU) and treatment groups (10, 250, and 750 mg kg⁻¹ day testosterone propionate + Propyl paraben). Propyl paraben (PP) significantly decreased all accessory sex organ weights at each dose of 250 and 750 mg kg⁻¹ day compared to control groups. Thus, we found that propyl paraben had antiandrogenic activity within the supported results of increasing LH levels and histopathologic results such atrophy, hyalinization, and anastomosis on androgenic tissues.

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使用Hershberger生物测定法评估对羟基苯甲酸丙酯的抗雄激素特性

尼泊金丙酯是在药物，化妆品和食品中广泛使用的防腐剂，可防止微生物和真菌污染。这项研究旨在使用Hershberger生物测定法研究10、250和750 mg kg ^-1天口服剂量对未成熟雄性大鼠的对羟基苯甲酸丙酯的抗雄激素作用。将大鼠分为六组，包括溶剂对照组，阴性对照组（0.4 mg kg ^-1天丙酸睾丸激素= TP），阳性对照组（3 mg kg ^-1天氟他胺= FLU）和治疗组（10、250和750 mg kg ^-1天丙酸睾丸酮+对羟基苯甲酸丙酯）。对羟基苯甲酸丙酯（PP）在250和750 mg kg ^-1的每种剂量下均显着降低了所有辅助性器官的重量每天与对照组比较。因此，我们发现对羟基苯甲酸丙酯在增加LH水平和组织病理学结果（如雄激素组织上的萎缩，透明化和吻合）的支持结果内具有抗雄激素活性。