Two studies show that genes that encode a chromatin-remodeling complex foster resistance to checkpoint inhibitors. One study identified the proteins by using CRISPR/Cas9 to knock out genes in mouse melanoma cells. The other study converged on the same result by identifying mutations in patients with clear cell renal cell carcinoma who responded to PD-1 inhibitors.

中文翻译：

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染色质重塑基因促进免疫治疗抗性

两项研究表明，编码染色质重塑复合物的基因可增强对检查点抑制剂的抗性。一项研究通过使用CRISPR / Cas9敲除小鼠黑素瘤细胞中的基因来鉴定蛋白质。另一项研究通过鉴定对PD-1抑制剂有反应的透明细胞肾细胞癌患者的突变，得出了相同的结果。