Inorganic nanoparticle-based biomedical imaging probes have been studied extensively as a potential alternative to conventional molecular imaging probes. Not only can they provide better imaging performance but they can also offer greater versatility of multimodal, stimuli-responsive, and targeted imaging. However, inorganic nanoparticle-based probes are still far from practical use in clinics due to safety concerns and less-optimized efficiency. In this context, it would be valuable to look over the underlying issues. This outlook highlights the recent advances in the development of inorganic nanoparticle-based probes for MRI, CT, and anti-Stokes shift-based optical imaging. Various issues and possibilities regarding the construction of imaging probes are discussed, and future research directions are suggested.

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用于生物医学成像的无机纳米粒子的最新发展

无机纳米粒子为基础的生物医学成像探针已被广泛研究作为常规分子成像探针的潜在替代品。它们不仅可以提供更好的成像性能，而且还可以提供更多的多模态，刺激响应性和靶向成像多功能性。但是，出于安全考虑和效率的优化不足，基于无机纳米粒子的探针仍远未在临床上实际使用。在这种情况下，仔细研究潜在问题将很有价值。这种前景突出了用于MRI，CT和基于反斯托克斯位移的光学成像的基于无机纳米粒子的探针的最新进展。讨论了有关成像探头构造的各种问题和可能性，并提出了未来的研究方向。