We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated tumor antigens to CD8⁺ T cells primarily through MHCI recycling and cross-dressing. EVIRs should facilitate exploring the mechanisms and implications of horizontal transfer of tumor antigens to antigen-presenting cells.

中文翻译：

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EVIR：增强树突状细胞与肿瘤抗原交叉的嵌合受体

我们描述了一种慢病毒编码的嵌合受体，称为细胞外囊泡 (EV) 内化受体 (EVIR)，它能够使树突状细胞 (DC) 选择性摄取癌细胞衍生的 EV。EVIR主要通过 MHCI 回收和交叉换药来增强 EV 相关肿瘤抗原向 CD8 ^{+ T 细胞的 DC 呈递。}EVIR 应该有助于探索肿瘤抗原水平转移到抗原呈递细胞的机制和影响。