A fungal strain, Drechmeria sp., was isolated from the root of Panax notoginseng. Totally, seven new indole diterpenoids, drechmerins A-G (1-7), were isolated from the fermentation broth of Drechmeria sp. together with four known analogues (8-11). Their structures were determined on the basis of 1D and 2D NMR and electronic circular dichroism (ECD) spectroscopic analyses as well as theoretical calculations. All the isolated compounds were evaluated for their antimicrobial activities against Candida albicans, Staphylococcus aureus, Bacillus cereus, B. subtillis, Pseudomonas aeruginosa, and Klebsiella pneumonia, respectively. Drechmerin B (2) displayed antimicrobial activity against C. albicans with an MIC value of 12.5 μg/mL. Molecular docking was used to investigate interactions of peptide deformylase with compounds 1-3, 5-7, 9, and 10.

中文翻译：

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来自内生真菌 Drechmeria sp. 的吲哚二萜。作为天然抗菌剂

从三七的根中分离出一种真菌菌株 Drechmeria sp.。总共从 Drechmeria sp. 的发酵液中分离出七种新的吲哚二萜类物质，drechmerins AG (1-7)。连同四种已知的类似物 (8-11)。它们的结构是根据一维和二维核磁共振和电子圆二色性 (ECD) 光谱分析以及理论计算确定的。分别评估了所有分离的化合物对白色念珠菌、金黄色葡萄球菌、蜡状芽孢杆菌、枯草芽孢杆菌、铜绿假单胞菌和肺炎克雷伯菌的抗菌活性。Drechmerin B (2) 显示出对白色念珠菌的抗菌活性，MIC 值为 12.5 μg/mL。分子对接用于研究肽去甲酰酶与化合物 1-3、5-7、9 和 10 的相互作用。