The asymmetric Mannich reaction is a very important method for C−C bond formation, and it is the classical method for the preparation of β‐amino ketones and aldehydes. The resulting β‐amino carbonyl compounds are widely found in nature, which attests to the importance of this reaction. This Focus Review provides an overview of asymmetric Mannich reactions, the various catalysts that have been used, and its applications, for papers published since 2013.

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不对称曼尼希反应的最新发展与展望

不对称曼尼希反应是形成C-C键的非常重要的方法，它是制备β-氨基酮和醛的经典方法。所得的β-氨基羰基化合物广泛存在于自然界中，这证明了该反应的重要性。本《焦点评论》概述了自2013年以来发表的论文的不对称曼尼希反应，已使用的各种催化剂及其应用。