The first total synthesis of (−)-xestosaprol N and O is described. This synthetic work features a convergent strategy: (1) a Pd-catalyzed arylation followed by cyclization to build a naphthalene fragment (ring C, D); (2) utilization of (−)-quinic acid to construct the chiral hydroxyl group at C-2; (3) a substrate controlled intramolecular Heck reaction to construct a quaternary carbon center (ring B); (4) introduction of a hypotaurine moiety at a late stage to furnish the E ring.

中文翻译：

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（-）-Xestosaprol N和O的全合成

描述了（-）-xestosaprol N和O的第一个全合成。这项合成工作具有收敛策略的特点：（1）Pd催化的芳基化反应，然后环化生成萘片段（C，D环）；（2）利用（-）-奎尼酸在C-2上构成手性羟基。（3）通过底物控制的分子内Heck反应来构建季碳中心（环B）；（4）在后期引入亚牛磺酸部分以提供E环。