We report here the construction of 3-way and 4-way peptide nucleic acid (PNA) junctions as basic structural units for PNA nanostructuring. The incorporation of amino acid residues into PNA chains makes PNA nanostructures with more structural complexity and architectural flexibility possible, as exemplified by building 3-way PNA junctions with tunable nanopores. Given that PNA nanostructures have good thermal and enzymatic stabilities, they are expected to have broad potential applications in biosensing, drug delivery and bioengineering.

中文翻译：

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可调肽核酸连接的构建

我们在此报告3向和4向肽核酸（PNA）连接的构建，作为PNA纳米结构的基本结构单元。将氨基酸残基掺入PNA链使得PNA纳米结构具有更大的结构复杂性和结构灵活性，例如通过构建带有可调纳米孔的3向PNA连接即可。鉴于PNA纳米结构具有良好的热稳定性和酶稳定性，预计它们将在生物传感，药物递送和生物工程领域具有广泛的潜在应用。