Partial thrombosis of the false lumen in uncomplicated type B aortic dissection (uTBAD) is associated with an increased late mortality risk. Whether the serum cortisol level can affect false lumen thrombosis in patients with uTBAD has not been well characterized. This study was performed on 87 patients with uTBAD. A curve-fitting method was used to analyze the relationship between serum cortisol and partial thrombosis of false lumen. Univariate and multivariate logistic regression analyses were used to identify false lumen partial thrombosis-associated serum cortisol. Curve-fitting's result revealed a characteristic U shape, and 14.0 µg/dL was considered as the cutoff point for serum cortisol. The results of univariate and multivariate logistic regression analyses suggested that when trisecting the serum cortisol level into three parts, the low and high levels of serum cortisol could significantly affect the occurrence of false lumen partial thrombosis compared with the middle level. The odds ratio value of the low and high levels of serum cortisol was 6.12 and 4.65, respectively, in the univariate analysis, and 24.32 and 3.93, respectively, in the multivariate analysis. Low or high levels of serum cortisol might influence the natural result of uTBAD through affecting the false lumen thrombosis.

中文翻译：

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单纯性B型主动脉夹层患者血清皮质醇水平与假管腔血栓形成程度的关系。

单纯性B型主动脉夹层（uTBAD）中假管腔的部分血栓形成与晚期死亡风险增加相关。尚未确定uTBAD患者血清皮质醇水平是否会影响假管腔血栓形成。这项研究是针对87例uTBAD患者进行的。采用曲线拟合法分析血清皮质醇与假管腔局部血栓形成之间的关系。单因素和多因素logistic回归分析用于识别假管腔局部血栓形成相关的血清皮质醇。曲线拟合的结果显示出特征性的U形，并且14.0 µg / dL被认为是血清皮质醇的临界点。单因素和多因素logistic回归分析的结果表明，将血清皮质醇水平分成三部分时，与中等水平相比，血清皮质醇的低和高水平可显着影响假管腔部分血栓的发生。在单变量分析中，低水平和高水平血清皮质醇的比值分别为6.12和4.65，在多变量分析中分别为24.32和3.93。血清皮质醇的低或高水平可能通过影响假管腔血栓形成而影响uTBAD的自然结果。