当前位置: X-MOL 学术Sci. Rep. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
The Direction of Tumour Growth in Glioblastoma Patients.
Scientific Reports ( IF 4.6 ) Pub Date : 2018-01-19 , DOI: 10.1038/s41598-018-19420-z
Morteza Esmaeili , Anne Line Stensjøen , Erik Magnus Berntsen , Ole Solheim , Ingerid Reinertsen

Generating MR-derived growth pattern models for glioblastoma multiforme (GBM) has been an attractive approach in neuro-oncology, suggesting a distinct pattern of lesion spread with a tendency in growing along the white matter (WM) fibre direction for the invasive component. However, the direction of growth is not much studied in vivo. In this study, we sought to study the dominant directions of tumour expansion/shrinkage pre-treatment. We examined fifty-six GBMs at two time-points: at radiological diagnosis and as part of the pre-operative planning, both with contrast-enhanced T1-weighted MRIs. The tumour volumes were semi-automatically segmented. A non-linear registration resulting in a deformation field characterizing the changes between the two time points was used together with the segmented tumours to determine the dominant directions of tumour change. To compute the degree of alignment between tumour growth vectors and WM fibres, an angle map was calculated. Our results demonstrate that tumours tend to grow predominantly along the WM, as evidenced by the dominant vector population with the maximum alignments. Our findings represent a step forward in investigating the hypothesis that tumour cells tend to migrate preferentially along the WM.

中文翻译:

胶质母细胞瘤患者肿瘤生长的方向。

为多形性胶质母细胞瘤(GBM)生成MR衍生的生长模式模型在神经肿瘤学中是一种有吸引力的方法,这表明病变扩散的模式独特,并有侵入性成分沿白质(WM)纤维方向生长的趋势。但是,在体内对生长方向的研究并不多。在这项研究中,我们试图研究肿瘤扩展/收缩预处理的主要方向。我们在两个时间点检查了56个GBM:在放射学诊断时和作为术前计划的一部分,均使用对比增强的T1加权MRI。肿瘤体积是半自动分割的。非线性配准产生的变形场表征了两个时间点之间的变化,并与分割后的肿瘤一起使用,以确定肿瘤变化的主要方向。为了计算肿瘤生长载体和WM纤维之间的排列程度,计算了角度图。我们的结果表明,肿瘤倾向于主要沿着WM增长,这由具有最大比对的优势载体群体所证明。我们的发现代表了在研究肿瘤细胞倾向于优先沿着WM迁移的假说方面迈出的一步。正如具有最大比对的优势向量种群所证明的那样。我们的发现代表了在研究肿瘤细胞倾向于优先沿着WM迁移的假说方面迈出的一步。正如具有最大比对的优势向量种群所证明的那样。我们的发现代表了在研究肿瘤细胞倾向于优先沿着WM迁移的假说方面迈出的一步。
更新日期:2018-01-19
down
wechat
bug