Our understanding of the complex molecular processes of living organisms at the molecular level is growing exponentially. This knowledge, together with a powerful arsenal of tools for manipulating the structures of macromolecules, is allowing chemists to to harness and reprogram the cellular machinery in ways previously unimaged. Here we review one example in which the genetic code itself has been expanded with new building blocks that allow us to probe and manipulate the structures and functions of proteins with unprecedented precision.

中文翻译：

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玩弄生命分子

我们对生物在分子水平上复杂的分子过程的理解正呈指数级增长。这种知识，加上强大的工具来操纵大分子的结构，使化学家能够以前所未有的方式利用和重新编程细胞机械。在这里，我们回顾一个例子，其中遗传密码本身已通过新的构建基元进行了扩展，使我们能够以前所未有的精度来探测和操纵蛋白质的结构和功能。