Although Jatropha aethiopica, popularly known in Cuba as “mata diabetes”, is used in salads and as a dietary supplement, its chemical composition and antidiabetic properties yet remains unclear. In this work, we evaluate the qualitative and quantitative composition of ethanolic extract (EE) and phenolic fraction (PF) of Jatropha aethiopica leaves and their hypoglycemic and hypolipidemic activity. Chemical fractionation of the ethanolic extract yielded nine compounds, which included protocatechuic acid (1), chlorogenic acid (2), caffeic acid (3), quercetin 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranolsyl-(1 → 6)]-β-d-galactopyranoside (4), a new kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 4)-[α-l-rhamnopyranolsyl-(1 → 6)]-β-d-galactopyranoside (5), kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 2)-[α-l-rhamnopyranolsyl-(1 → 6)]-β-d-glucopyranoside (6), rutin (7), kaempferol 3-O-α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside (8), and quercetin (9). The compounds (1, 4–7) were quantified by high-performance liquid chromatography photodiode array detection (HPLC-PDA) in both the ethanolic extract (62.65 ± 0.15 mg/g) and phenolic fraction (61.72 ± 0.23 mg/g). The results obtained show that both ethanolic extract and phenolic fraction contributed toward the improvement of glucose tolerance, which in turn led to a decline in the glucose levels. Remarkably, the ethanolic extract presented a relatively higher promising effect compared to metformin.

中文翻译：

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麻风树麻风树乙醇提取物和酚类成分的定性和定量分析及其降血糖潜力

尽管麻风树麻风树在古巴普遍被称为“ mata糖尿病”，但已用于沙拉和膳食补充剂中，但其化学成分和抗糖尿病特性仍不清楚。在这项工作中，我们评估麻风树麻风树叶片的乙醇提取物（EE）和酚类成分（PF）的定性和定量组成及其降血糖和降血脂活性。乙醇提取物的化学分馏得到9项的化合物，其包含原儿茶酸（1），绿原酸（2），咖啡酸（3），槲皮素-3- ö -α-升-rhamnopyranosyl-（1→2） - [α- 1- rhamnopyranolsyl-（1→6）]-β-d -galactopyranoside（4），一个新的山奈酚3- ö -α-升-rhamnopyranosyl-（1→4） - [α-升-rhamnopyranolsyl-（1→6）] - β- d -galactopyranoside（5），山柰酚3- ø -α-升-rhamnopyranosyl-（1→2） - [α-升-rhamnopyranolsyl-（1→6）] - β- d吡喃葡萄糖苷（6），芦丁（7），山柰酚3- ö -α -升-rhamnopyranosyl-（1→6）-β- d吡喃葡萄糖苷（8），槲皮素（9）。的化合物（1，4-7通过高效液相色谱光电二极管阵列检测（HPLC-PDA）对乙醇提取物（62.65±0.15 mg / g）和酚类馏分（61.72±0.23 mg / g）进行定量。获得的结果表明，乙醇提取物和酚类馏分均有助于改善葡萄糖耐量，进而导致葡萄糖水平下降。值得注意的是，与二甲双胍相比，乙醇提取物具有相对较高的有希望的作用。